My laboratory primary goal is to decipher the molecular mechanisms driving pathological inflammation and fibrogenesis. One of the goals of my research program is to test the hypothesis that blocking the bidirectional Eph/Ephrin signaling is required for the resolution of inflammation and fibrosis across various organ including the liver. My long-term goal is to utilize my findings to develop Ephrin-based therapeutic agents for the treatment of fibrotic disorders, including fatty liver-induced hepatocellular carcinoma. My prior research was original focused on understanding the role of axon guidance cues “Eph receptors” in the pathogenesis of cerebral malaria infection. Surprisingly, I discovered that EphB2 contributes to malaria-associated hepatic fibrosis (Hepatology, 2015). My findings were the first report of the involvement of this molecule in the pathogenesis of fibrosis.
Ph.D. - EMBL and London School of Hygiene and Tropical Medicine, UK 6/2010
Post-doctoral Fellowship - Emory University School of Medicine, Atlanta, GA 01/2016
